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Clinical Research on Humans
The following selection of trials has been selected on the basis of their positive findings in favour of Homeopathy. The reason for this is twofold

-There is a need to show Homeopathy in a positive light especially as much of the press is only too ready to print unfavourable reports and
- The negative findings are invariably a result of a violation of one or more Homeopathic principles in the trials basic design. The trial have not been constructed to incorporate Homeopathic principles. The Homeopathic community will continue to refute such ill conceived trials and mankind will be no nearer a solution unless agreement can be found.

Below is a summary of the more common violations of Homeopathic principle found in many trial designs
- No allowance is made for individualisation. Such trials are conceived according to allopathic principles of medicine (ie a remedy at a standard treatment rate for the same disease). This is not Homeopathy.
- Homeopathy treats a diseased patient not a disease. Flexibility of remedy potency, dosage, and duration is at its heart. Unlike allopathy there is no such thing as a standard treatment.
-  Definition of cure (or benefit) is another problem. The allopathic drug only needs to show amelioration (suppression) of the disease condition to score a benefit. No reference is made to permanency of cure and whether the condition returned following withdrawal of the allopathic drug. Homeopathy strives to cure the condition by strengthening the natural immunity and thus affecting a permanent solution.
- Because of the nature of the Homeopathic action (through the natural immune system) benefit especially in chronic cases is seldom quick. On the other hand benefit from suppression can often be relative quick. Many trials are terminated when a benefit shows for the allopathic drug and the Homeopathic remedy is written off as ineffective when the real reason is that insufficient time has been allowed for its slower curative action to work through.
-  No allowance is made for Homeopathic aggravation. There can often be, in chronic cases, a period of Homeopathic aggravation which in Homeopathic terms is interpreted favourably. However some trials have been terminated at the first sign of aggravation and the conclusion drawn that the Homeopathic remedy performed worse than the placebo.

In conclusion this problem will continue to run until such time as Homeopaths are brought into the trial design stage along with their allopathic colleagues and allowed to take part in the peer review process. In an attempt to kick start this process I have made some suggestions under the paragraph entitled Limitations of RCTs and a Way Forward

Clinical Trials on Humans
(RDBPC = Randomised double blinded placebo controlled trial)

Clinical trials are those trials which target a specific illness or disease
Due to their large number the following have been selected as representative of the positive findings published in peer reviewed scientific and medical journals.

1. RDBPC trial of 242 participants allergic to house dust. Differences exist between homeopathic immunotherapy and placebo for which we have no explanation
(Lewith, G.T., Watkins, A.D., Hyland, M.E., Shaw, S., Broomfield, J.A., Dolan, G., and Holgate, S.T. "Use of Ultramolecular Potencies of Allergen To Treat Asthmatic People Allergic to House Dust Mite: Double Blind Randomised Controlled Clinical Trial." British Medical Journal. 2002. 324(7336):520-4.)

2. RDBPC trial with 51 patients suffering from allergic rhinitis concluded homeopathic dilutions differ from placebo
(Taylor, M.A., Reilly, D., Llewellyn-Jones, R.H., McSharry, C., and Aitchison, T.C. "Randomised Controlled Trial of Homoeopathy versus Placebo in Perennial Allergic Rhinitis with Overview of Four Trial Series." British Medical Journal. 2000. 321(7259):471-6.)

3. Homeopathic treatment had a positive effect on basophils reducing chemical allergy causing chemicals.
(Jean Boiron. Jacky Abecassls. and Philippe Belon. "The Effects of Hahnemannian Potencies of 7c Histaminum and 7c Apis Mellifica upon Basophil Degranulation in Allergic Patients." Aspects of Research in Homoepathy (Lyon: Boiron, 1983), pp. 61-66.)

Anti Cancer
Fifty two per cent of mice receiving a Fibrosarcoma transplant survived for more than one year on homeopathic remedies whereas untreated mice died within 10-15 days.
(Choudhury, "Cure of Cancer in Experimental Mice with Certain Biochemic Salts," British Homeopathic Journal, 69 (1980): 168-170.)

Anti- Cholesterol
Homeopathic Chelidonium lowered serum cholesterol in rabbits.
(V. Baumans, C.J. Bol, W.M.T. oWe Luttikhuis, and A.C. Beynen. "Does Chelidonium 3X Lower Serum Cholesterol?" British Homeopathic Journal, 76 (January 1987): 14-15.)

RDBPC trial demonstrated an anti-viral effect between 50 100% in 8 out of 10 homeopathic remedies depending on potency.
(L.M. Singh and G. Gupta, "Antiviral Efficacy of Homeopathic Drugs Against Animal Viruses," British Homeopathic Journal, 74 (July 1985): 168-174.)

Arthritis Rheumatoid
RDBPC study in which 82% of patients of Rheumatoid Arthritis experienced relief of symptoms whilst only 21% of those on placebo had similar relief.
(PG. Gibson, S. L.M. Gibson, AD. MacNeil. et al.. "Homeopathic Therapy in Rheumatoid Arthritis: Evaluation Double-Blind Controlled Trial,"British Journal of Clinical Pharmacology, 9 (1980): 453-459.)

Dental Neuralgia
RDBPC study on patients following tooth extraction showed 76% benefited from pain relief following homeopathic treatment.
(Henry Albertini et al.. "Homeopathic Treatment of Neuralgia Using Arnica and Hypericum: A Summary of 60 Observations," Journal of the American Institute of Homeopathy. 78 (September 1985): 126-128.)

Homeopathic doses of arsenic eliminated trapped toxic crude arsenic when administered to arsenic toxified rats.
(J.C. Cazin et al. "A Study of the Effect of Decimal and Centesimal Dilution of Arsenic on Retention and Mobilization of Arsenic in the Rat," Human Toxicology, July 1987.)

RDBPC trial of 1226 children found that an individualized treatments improved digestive problemsassociated with diarrhea.
(Jacobs, J., Jimenez, L.M., Malthouse, S., Chapman, E., Crothers, D., Masuk, M., and Jonas, W.B. "Homeopathic Treatment of Acute Childhood Diarrhea: Results from a Clinical Trial in Nepal." Journal of Alternative and Complementary Medicine. 2000. 6(2):131-9.)

RDBPC trial of 79 males and 29 females found those receiving homeopathic treatment had increased levels of CD4 whereas the placebo did not.
(Rastogi, D.P., Singh, V.P., Singh, V., Dey, S.K., and Rao, K. "Homeopathy in HIV Infection: A Trial Report of Double-Blind Placebo Controlled Study." British Homeopathic Journal. 1999. 88(2):49-57.)

Immunological Response
A stimulating relationship between homeopathic silica and macrophages (which destroy allergens) was shown to exist.
(Elizabeth Davenas. Bernard Poitevin, and Jacques Benveniste, Effect on Mouse Peritoneal Macrophages of Orally Administered Very High Dilutions of Silica,"European Journal of Pharmacology. 135 (April 1987): 313-319.)

Pain Relief
Study demonstrated that pain relief was obtained from homeopathic hypericum  as demonstrated by increased endorphin pain inhibiting acivity.
(G.R. Keysall, K.L. Williamson, and B.D. Tolman. "The Testing of Some Homeopathic Preparations in Rodents, "Proceedings of the 40th International Homeopathic Congress (Lyon. France, 1985). pp. 228-231,)


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